AGIO — AGIOS PHARMACEUTICALS, INC.

Nasdaq · Health Care · Pharmaceuticals · CIK 1439222 ·
Last close
$33.08
Market Cap
$1.97B
52W High
$36.35
52W Low
$24.29
ADV30
900,727
Next earnings
2026-07-30
Agios Pharmaceuticals, Inc., a biopharmaceutical company, discovers and develops medicines in the field of cellular metabolism in the United States. Its lead product includes PYRUKYND (mitapivat), an activator of wild-type and mutant pyruvate kinase (PK), enzymes used for the treatment of hemolytic anemias in adults with PK deficiency. The company's PYRUKYND product is also used for the treatment of sickle cell disease that is in phase 3 clinical trial; for the treatment of PK deficiency in pediatric patients; and AQVESME for the treatment of adult patients with non-transfusion dependent and transfusion-dependent alpha- or beta-thalassemia. In addition, it developed tebapivat, a PK activator for the treatment of lower-risk myelodysplastic syndrome and sickle cell disease; AG-181, a phenylalanine hydroxylase stabilizer for the treatment of phenylketonuria (PKU); and AG-236, an siRNA in-licensed from Alnylam, targeting the transmembrane serine protease 6 (TMPRSS6) gene for the treatment of polycythemia vera. Agios Pharmaceuticals, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 20,746,000 19,427,000 -110,025,000 -99,111,000 1,184,990,000 113,600,000 75,875,000
Dec 2025 19,967,000 18,088,000 -121,578,000 -108,039,000 1,297,225,000 89,130,000 104,111,000
Sep 2025 12,880,000 11,201,000 -116,869,000 -103,433,000 1,385,705,000 92,710,000 101,375,000
Jun 2025 12,455,000 10,753,000 -127,056,000 -112,020,000 1,471,237,000 80,871,000 101,682,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-380,408,000
Investing CF
$405,909,000
Financing CF
$9,135,000
CapEx
$-14,319,000
Dividends Paid
Buybacks
EPS Diluted TTM
$11.20
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-802,486,000
Inventory
$35,087,000
Receivables
$10,577,000
ST Investments
$765,295,000
EBIT TTM
$-475,528,000
Pretax Income TTM
$-423,619,000
Interest Exp TTM
Analysts
8

Yahoo Snapshot (yfinance, live)

Total Revenue
$66,048,000
EBITDA
$-470,265,984
Free Cash Flow
$-267,222,000
Enterprise Value
$1,192,283,008
Total Cash
$737,038,016
Total Debt
$35,745,000
Shares Out
59,471,609
Trailing EPS
$-7.26
Book Value
$18.69
ROE
-32.8%
ROA
-21.7%
Div Yield

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 54,028,000 -472,132,000 -412,781,000 1,297,225,000 104,111,000 -372,977,000
Dec 2024 36,498,000 -425,737,000 673,725,000 1,663,199,000 122,243,000 -389,841,000
Dec 2023 26,823,000 -391,487,000 -352,088,000 937,118,000 126,099,000 -296,062,000
Dec 2022 14,240,000 -389,047,000 -231,801,000 1,238,718,000 137,904,000 -309,478,000

TTM Snapshot

Revenues TTM
$19,879,000
NetIncome TTM
$686,078,000
OpCashFlow TTM
$0
Assets (Latest)
$1,663,199,000
Forward EPS
$-4.72

Max Pain — expiry 2027-01-15

max pain strike: $25.00 · spot: $33.08 · call oi: 8 · put oi: 2,282
Expected Move to 2027-01-15: ±$15.60 (47.16%) — implied range $17.48$48.68 · ATM straddle on $35.00 strike

Peers — same industry

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MBX MBX Biosciences, Inc. $1.98B $41.59
HRMY Harmony Biosciences Holdings, Inc. $1.96B $33.77
ZLAB Zai Lab Ltd $2.01B $17.88
BHVN Biohaven Ltd. $2.05B $13.62
STOK Stoke Therapeutics, Inc. $1.88B $30.26

News headlines (Yahoo Finance, 1h cache)

Agios Pharmaceuticals Touts Mitapivat Gains Despite Sickle Cell Pain Miss
2026-06-13 18:05 · Yahoo
Agios Showcases RISE UP Phase 3 Results at EHA 2026 Plenary Session Reinforcing Strong Anti-Hemolytic Profile of Mitapivat in Sickle Cell Disease
2026-06-13 13:00 · Yahoo
Exelixis (EXEL) Up 6% Since Last Earnings Report: Can It Continue?
2026-06-04 15:30 · Yahoo
How The Tebapivat Setback Is Reframing The Story For Agios Pharmaceuticals (AGIO)
2026-06-03 13:12 · Yahoo
AGIO Secures Global Rights to Late-Stage Rare Blood Disorder Candidate
2026-06-02 14:24 · Yahoo
Agios Pharmaceuticals licenses global rights to Oscotec's SYK inhibitor cevidoplenib
2026-06-01 16:26 · Yahoo
AGIO Halts Tebapivat Development in Myelodysplastic Syndromes
2026-06-01 13:43 · Yahoo
Agios Enters Exclusive Global License Agreement with Oscotec to Develop and Commercialize Next-Generation SYK Inhibitor Cevidoplenib
2026-06-01 09:00 · Yahoo
Why Is Agios Pharmaceuticals (AGIO) Up 8.6% Since Last Earnings Report?
2026-05-29 15:30 · Yahoo
Agios slides after discontinuing development of tebapivat in myelodysplastic syndromes (AGIO)
2026-05-29 14:26 · Yahoo

Recent Insider Activity

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