DNLI — Denali Therapeutics Inc.

Nasdaq · Health Care · Biotechnology · CIK 1714899 ·
Last close
$23.02
Market Cap
$3.65B
52W High
$27.30
52W Low
$17.71
ADV30
1,869,852
Next earnings
Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzyme TransportVehicle (TV) programs include DNL952 for the treatment of Pompe disease; DNL111 for Parkinson's and Gaucher diseases; and DNL622 for Hurler syndrome (MPS I). The company's OTV programs also comprise DNL628 targeting tau for Alzheimer's disease; and DNL422 targeting alpha synuclein for Parkinson's disease, as well as antibody TV program includes DNL921 targeting Abeta for treating Alzheimer's disease. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 0 -137,357,000 -128,447,000 1,266,023,000 387,626,000 339,925,000
Dec 2025 0 -137,365,000 -128,549,000 1,144,854,000 205,326,000 131,093,000
Sep 2025 0 -137,434,000 -126,902,000 1,055,621,000 90,963,000 129,424,000
Jun 2025 0 -134,963,000 -124,119,000 1,166,241,000 141,207,000 139,188,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-412,600,000
Investing CF
$255,281,000
Financing CF
$189,216,000
CapEx
$-15,972,000
Dividends Paid
Buybacks
EPS Diluted TTM
$-2.97
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-2,051,524,000
Inventory
Receivables
$2,177,000
ST Investments
$662,553,000
EBIT TTM
$-555,342,000
Pretax Income TTM
$-512,438,000
Interest Exp TTM
Analysts
14

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 0 -555,342,000 -512,540,000 1,144,854,000 131,093,000 -412,600,000
Dec 2024 0 -501,878,000 -422,773,000 1,374,180,000 144,496,000 -347,694,000
Dec 2023 330,531,000 -196,699,000 -145,224,000 1,153,917,000 122,963,000 -357,991,000
Dec 2022 108,463,000 -340,744,000 -325,991,000 1,460,242,000 417,812,000 -244,716,000

TTM Snapshot

Revenues TTM
$10,111,000
NetIncome TTM
$-394,432,000
OpCashFlow TTM
$0
Assets (Latest)
$1,374,180,000
Forward EPS
$-2.53

Peers — same industry

TickerNameMarket CapLastDaily %
ADPT Adaptive Biotechnologies Corp $3.59B $22.57
RLAY Relay Therapeutics, Inc. $4.10B $18.83
CRSP CRISPR Therapeutics AG $4.73B $47.99
BEAM Beam Therapeutics Inc. $2.63B $25.52
KOD Kodiak Sciences Inc. $2.60B $41.58

News headlines (Yahoo Finance, 1h cache)

Denali Therapeutics to Report Second Quarter 2026 Financial Results and Business Highlights on August 6, 2026
2026-07-27 20:01 · Yahoo
Denali Therapeutics (DNLI) Heads To AAIC, Is The Stock Already Pricey?
2026-07-22 23:13 · Yahoo
Is Denali Therapeutics (DNLI) Overvalued After Its FDA Approval?
2026-07-22 17:11 · Yahoo
Beyond weight loss: Lilly aims for leadership in brain science
2026-07-21 09:23 · Yahoo
VERAXA Biotech Shows Regulatory Progress on Cancer Therapy Platform
2026-07-20 16:15 · Yahoo
Slate Medicines Appoints Mark W. Hahn to Board of Directors
2026-07-16 16:18 · Yahoo
Will Recent Setbacks Impact Growth Prospects of DNLI Stock?
2026-07-15 17:02 · Yahoo
Can Biogen Convince Skeptics That Cutting a Rogue Protein Slows Alzheimer’s?
2026-07-13 06:00 · Yahoo
Denali Therapeutics to Give Opening Plenary Address at Alzheimer’s Association International Conference (AAIC) 2026 and Highlight Breakthroughs in Delivering Biologic Therapies Across Blood-Brain Barr
2026-07-09 20:01 · Yahoo
Regenxbio Shares Rise on Plans to Resubmit Navsunli BLA for MPS II
2026-06-23 14:46 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.