KPTI — Karyopharm Therapeutics Inc.

Nasdaq · Health Care · Pharmaceuticals · CIK 1503802 ·
Last close
$9.50
Market Cap
$215.30M
52W High
$10.23
52W Low
$5.00
ADV30
425,093
Next earnings
2026-08-11
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma; in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma; and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). It also develops Selinexor for treating hematological and solid tumor malignancies, including multiple myeloma, endometrial cancer, myelofibrosis, and DLBCL; and ELTANEXOR for treating other myeloproliferative neoplasms and TP53 wild-type solid tumors. In addition, the company has license agreement with Menarini Group to develop and commercialize selinexor for human oncology indications; license agreement with Antengene Therapeutics Limited to develop and commercialize selinexor, eltanexor, and KPT-9274 for the treatment and/or prevention of human oncology indications, as well as verdinexor for the diagnosis, treatment, and/or prevention of human non-oncology indications; and distribution agreement for the commercialization of XPOVIO with FORUS Therapeutics Inc. Further, the company has a collaboration with Bristol Myers Squibb company to evaluate novel cereblon E3 ligase modulator agent mezigdomide in combination with Selinexor in patients with relapsed or refractory multiple myeloma. Karyopharm Therapeutics Inc. was incorporated in 2008 and is headquartered in Newton, Massachusetts.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 35,066,000 33,721,000 -26,760,000 -22,392,000 131,417,000 90,850,000 397,063,000
Dec 2025 34,079,000 32,595,000 -17,844,000 -102,198,000 108,416,000 60,540,000 401,342,000
Sep 2025 44,044,000 41,931,000 -15,220,000 -33,127,000 96,232,000 37,672,000 365,490,000
Jun 2025 37,929,000 36,878,000 -24,387,000 -37,252,000 104,879,000 38,725,000 343,805,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-59,113,000
Investing CF
$31,290,000
Financing CF
$79,850,000
CapEx
Dividends Paid
Buybacks
EPS Diluted TTM
$-15.09
As of
2026-06-07

Balance + Analyst (yfinance extras)

Retained Earnings
$-1,781,891,000
Inventory
$3,599,000
Receivables
$23,357,000
ST Investments
$0
EBIT TTM
$-147,553,000
Pretax Income TTM
$-194,961,000
Interest Exp TTM
$47,408,000
Analysts
6

Yahoo Snapshot (yfinance, live)

Total Revenue
$151,118,000
EBITDA
$-83,919,000
Free Cash Flow
Enterprise Value
$420,044,000
Total Cash
$90,850,000
Total Debt
$296,726,016
Shares Out
22,662,943
Trailing EPS
$-16.40
Book Value
$-11.78
ROE
ROA
-40.6%
Div Yield

Annual Trend (SEC EDGAR, last 5y)

Revenues vs Net Income (last 5y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 146,067,000 -90,707,000 -196,039,000 108,416,000 401,342,000 -75,369,000
Dec 2024 145,237,000 -119,443,000 -76,422,000 164,418,000 350,435,000 -127,486,000
Dec 2023 146,033,000 -129,540,000 -143,099,000 240,438,000 376,644,000 -92,723,000
Dec 2022 157,074,000 -142,202,000 -165,291,000 358,172,000 374,828,000 -149,554,000
Dec 2021

TTM Snapshot

Revenues TTM
NetIncome TTM
OpCashFlow TTM
Assets (Latest)
Forward EPS
$-4.89

Max Pain — expiry 2026-08-21

max pain strike: $7.50 · spot: $9.61 · call oi: 17,621 · put oi: 423
Expected Move to 2026-08-21: ±$4.70 (48.91%) — implied range $4.91$14.31 · ATM straddle on $10.00 strike

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ALXO ALX ONCOLOGY HOLDINGS INC $212.61M $1.58

News headlines (Yahoo Finance, 1h cache)

Menarini Group Reports Data from the Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis at The European Hematology Association (EHA) 2026 Congress
2026-06-14 13:57 · Yahoo
Menarini Group Reports Data from the Phase 3 SENTRY Trial of Selinexor (NEXPOVIO®) Plus Ruxolitinib in Myelofibrosis at The European Hematology Association (EHA) 2026 Congress
2026-06-14 10:30 · Yahoo
How The Investment Story Is Evolving For Karyopharm Therapeutics (KPTI)
2026-06-07 11:06 · Yahoo
Karyopharm to Participate in Webcast Featuring Endometrial Cancer Key Opinion Leader on June 8, 2026
2026-06-03 20:15 · Yahoo
Karyopharm's Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis Selected for Late-Breaking Oral Presentation at EHA 2026
2026-06-02 14:02 · Yahoo
Karyopharm to Present Results from Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis in Late-Breaking Oral Presentation at ASCO 2026 with Simultaneous Publication in the Journal of C
2026-06-02 12:59 · Yahoo
Karyopharm Therapeutics Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)
2026-06-01 20:05 · Yahoo
Karyopharm to Host Investor Conference Call Featuring Expert Perspectives on the Phase 3 SENTRY Trial in Myelofibrosis Following 2026 ASCO Presentation
2026-06-01 11:30 · Yahoo
Karyopharm to Participate at the 2026 Jefferies Global Healthcare Conference
2026-05-28 11:30 · Yahoo
Wall Street Analysts Think Karyopharm Therapeutics (KPTI) Could Surge 70.46%: Read This Before Placing a Bet
2026-05-27 13:55 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.